Statins reduce pancreatitis risk
medwireNews: Statins reduce the risk for pancreatitis in patients with normal or mildly elevated triglyceride levels, say the authors of a large meta-
By contrast, the authors found that there was no association between use of fibrates and pancreatitis risk, contradicting the advice of several guidelines.
"Although lipid guidelines recommend fibrate therapy to reduce pancreatitis risk in persons with hypertriglyceridemia, fibrates may lead to the development of gallstones, a risk factor for pancreatitis," say David Preiss (University of Glasgow, UK) and colleagues.
The researchers gathered data on incident pancreatitis from large, high-
The authors, reporting in JAMA, found that in placebo-
In contrast the risk for pancreatitis in fibrate-
The authors say the reduction in pancreatitis associated with statin treatment versus placebo may be due to a reduction in bile acid, and that statins, unlike fibrates, also reduce the risk for gallstones. Prior recommendations have advocated fibrate use for moderately elevated triglyceride levels because hyperglyceridemia is known to be a cause of pancreatitis. However, in this meta-
The findings also contrast with previous case and observation studies that have reported statins may increase the risk for pancreatitis. The authors say that their analysis, which was based on randomized trials and considered only incident cases of pancreatitis, is less susceptible to bias by confounders.
They conclude: "The analysis raises questions regarding the choice of lipid-
By Kirsty Oswald, medwireNews Reporter-